Table 1.
Dorsal striatum | Nucleus accumbens | |||
---|---|---|---|---|
WT | TH-Cre | WT | TH-Cre | |
DOPAC | 15.2 ±2.30 | 16.5 ±2.00 | 3.5 ±0.80 | 1.9 ±0.30 |
DA | 28.4 ±3.20 | 29.2 ±3.20 | 9.6 ±0.90 | 6.9 ±0.90 |
5-HT | 10.9 ±2.10 | 10.5 ±1.50 | 1.4 ±0.70 | 0.6 ±0.40 |
HIAA | 1.7 ±0.40 | 2.2 ±0.30 | 0.6 ±0.10 | 0.8 ±0.20 |
NA | 0.2 ±0.00 | 0.2 ±0.04 | 0.3 ±0.10 | 0.5 ±0.20 |
HPLC analysis of striatal areas including dorsal striatum (dStr) and nucleus accumbens (NAc) of hemizygous TH-Cre and littermate controls (n = 5). DOPAC; dihydroxyphenylacetic acid. 5-HIAA; 5-hydroxyindoleacetic acid, 5-HT; 5-hydroxytryptamine, NA; norepinephrine. Data are shown as mean +/− SEM.