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. 2017 Feb 7;7:42070. doi: 10.1038/srep42070

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SP-defined GSCs exhibit lower PpIX accumulation in 5-ALA-based PDD, potentially due to accelerated iron usage to convert PpIX to heme and the increased expression of HO-1 to accelerate PpIX-heme metabolism. The combined use of an iron chelator DFO dramatically restores the decreased accumulation of PpIX in SP-defined GSCs.