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. 2017 Feb 7;7:42317. doi: 10.1038/srep42317

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(a) The total lung resistance (R_rs) to methacholine shows a dose-response relationship to increasing concentrations of N-SOA with the methacholine dose-responsive curves for N-SOA 100 μg/m³ and N-SOA 150 μg/m³ (^#p < 0.05, n = 6–11/group). (b) The maximum resistance (R_rs max) showed significant dose-responsive increased to progressively higher concentrations of N-SOA (p < 0.05, r = 0.627, Spearman correlation, n = 6–11/group).