Table 4. Multivariable analysis of factors independently associated with 1-year cause-specific mortality.
| Death from colon cancer (hazard ratio (95% CI)) | Death from cardiovascular disease (hazard ratio (95% CI)) | |
|---|---|---|
| Age | ||
| <65 | Reference | Reference |
| 65–74 | 1.59 (1.26–2.00) | 3.72 (2.29–6.05) |
| ⩾75 | 2.57 (2.09–3.16) | 7.02 (4.44–11.10) |
| Postoperative complication | ||
| Sepsis | 2.58 (2.13–3.11) | 2.33 (1.81–2.99) |
| Pneumonia | 2.15 (1.39–3.34) | 2.37 (1.44–3.89) |
| Abdominal abscess | 1.57 (1.18–2.08) | 1.19 (0.77–1.84) |
| Myocardial infarction | 1.49 (1.10–2.03) | 1.59 (1.12–2.25) |
| Gastrointestinal bleeding | 1.08 (0.85–1.37) | 1.42 (1.08–1.86) |
|
Other patient factors | ||
| Comorbidities | ||
| Congestive heart failure | 1.20 (1.01–1.43) | 2.38 (1.95–2.91) |
| Peripheral vascular disease | 0.96 (0.74–1.24) | 1.86 (1.44–2.41) |
| Renal failure | 1.11 (0.88–1.39) | 1.73 (1.35–2.21) |
| Anaemia | 1.53 (1.27–1.84) | 1.03 (0.79–1.34) |
| Unscheduled admission | 1.85 (1.59–2.14) | 1.51 (1.23–1.84) |
| Blood transfusion | 1.16 (1.01–1.34) | 1.19 (0.98–1.44) |
| Discharge to healthcare facility | 1.50 (1.29–1.75) | 2.68 (2.19–3.27) |
|
Oncologic factors | ||
| AJCC stage | ||
| I | Reference | Reference |
| II | 2.14 (1.66–2.77) | 1.10 (0.89–1.37) |
| III | 5.40 (4.20–6.94) | 0.97 (0.77–1.23) |
| Tumour grade | ||
| 1 | Reference | – |
| 2 | 1.06 (0.78–1.42) | – |
| 3/4 | 2.24 (1.65–3.04) | – |
| Unknown | 2.01 (1.32–3.07) | – |
| Receipt of adjuvant chemotherapy | 0.66 (0.55–0.78) | – |
|
Operative factors | ||
| Type of colectomy | ||
| Right | Reference | Reference |
| Left | 1.15 (1.00–1.33) | 1.04 (0.86–1.27) |
| Partial | 1.30 (0.94–1.79) | 1.13 (0.74–1.73) |
| Total | 1.15 (0.64–2.06) | 1.10 (0.51–2.37) |
| Operative approach | ||
| Open | Reference | Reference |
| Minimally invasive | 0.77 (0.63–0.94) | 0.89 (0.68–1.16) |
| Year of surgery | ||
| 2004–2005 | Reference | Reference |
| 2006–2007 | 0.86 (0.72–1.01) | 0.92 (0.74–1.15) |
| 2008–2009 | 0.92 (0.78–1.10) | 0.85 (0.67, 1.09) |
| 2010–2011 | 0.61 (0.50–0.76) | 0.51 (0.38–0.68) |
|
Surgeon factors | ||
| Board-certification | ||
| Surgery | Reference | Reference |
| Colorectal surgery | 0.77 (0.62–0.94) | 0.82 (0.62–1.07) |
| Annual colon cancer resection volume | ||
| Low (1–5) | Reference | Reference |
| Medium (5–10) | 0.86 (0.74–1.01) | 1.11 (0.89–1.38) |
| High (>10) | 0.83 (0.71–0.98) | 1.09 (0.87–1.37) |