Figure 2.

Geometric mean levels (pmol mg⁻¹ creatinine) of 12 EMs that we measured in urine samples from 60 premenopausal women; 30 carriers of the CYP3A7*1C allele (light grey) and 30 non-carriers (dark grey). Estimates are the average of two samples per woman, taken on sequential days, calculated to be at or around ovulation based on the woman's usual menstrual cycle length. Error bars represent s.e. Levels of two of the 4-hydroxylation pathway EMs (4-MeOE₁ and 4-MeOE₂) were below detection in 92 (4-MeOE₁) and 107 (4-MeOE₂) of the samples analysed. These two EMs were, therefore, excluded.