Table 2. Percentage difference (95% CI) in urinary EM levels comparing CYP3A7*1C carriers with non-carriers.

Grouped EM	Individual EM	% Difference in EMa,b (95% CI)	P-value
Total EMs		−15.1 (−32.7, 7.0)	0.16
Parent EMs		−41.0 (−57.2, −18.5)	0.002
	Oestrone	−45.3 (−60.6, −24.1)	0.0005
	Estradiol	−26.7 (−47.5, 2.2)	0.07
Catechol EMs		−71.0 (−80.1, −57.9)	1.2 × 10−8
2-Catechol EMs		−76.1 (−83.0, −66.6)	8.4 × 10−12
	2-Hydroxyestronec	−78.3 (−84.5, −69.6)	1.1 × 10−12
	2- Hydroxyestradiol	−67.9 (−78.3, −52.6)	2.7 × 10−7
4-Catechol EMs
	4-Hydroxyestrone	−51.8 (−72.9, −14.2)	0.01
Methylated catechol EM
Methylated 2-catechol EM		−73.5 (−81.2, −62.7)	1.9 × 10−10
	2-Methoxyestrone	−81.2 (−87.1, −72.6)	1.9 × 10−12
	2-Methoxyestradiolc	−62.8 (−78.9, −34.7)	0.0009
	2-Hydroxyestrone-3-methyl etherc	−21.9 (−50.3, 22.6)	0.28
Methylated 4-catechol EMs
	4-Methoxyestrone	NA	NA
	4-Methoxyestradiol	NA	NA
2-Hydroxylation pathway EMs		−74.9 (−81.6, −65.8)	1.6 × 10−12
4-Hydroxylation pathway EMs		−51.8 (−72.9, −14.2)	0.01
16-Hydroxylation pathway EMs		34.7 (1.6, 78.5)	0.04
	16α-Hydroxyestrone	91.6 (20.2, 205.1)	0.007
	17-Epiestriol	160.1 (46.0, 363.4)	0.002
	Estriol	25.5 (−5.1, 66.0)	0.11
	16-Ketoestradiolc	62.4 (8.7, 142.7)	0.02

Abbreviations: CI=confidence interval; EM=oestrogen metabolite; NA=not available.

^aUnadjusted analysis.

^bA negative difference may be interpreted as lower levels in CYP3A7*1C carriers compared with non-carriers.

^cMissing values: 2-OHE₂, 1 sample (non-carrier); 2-MeOE₂, 11 samples (11 women, 2 non-carriers, 9 carriers); 3-MeOE₁, 11 samples (9 women, 2 non-carriers, 7 carriers), 16-ketoE₂, 5 samples (3 women, 2 non-carriers, 1 carrier).