Table 2. Percentage difference (95% CI) in urinary EM levels comparing CYP3A7*1C carriers with non-carriers.
Grouped EM | Individual EM | % Difference in EMa,b (95% CI) | P-value |
---|---|---|---|
Total EMs | −15.1 (−32.7, 7.0) | 0.16 | |
Parent EMs | −41.0 (−57.2, −18.5) | 0.002 | |
Oestrone | −45.3 (−60.6, −24.1) | 0.0005 | |
Estradiol | −26.7 (−47.5, 2.2) | 0.07 | |
Catechol EMs | −71.0 (−80.1, −57.9) | 1.2 × 10−8 | |
2-Catechol EMs | −76.1 (−83.0, −66.6) | 8.4 × 10−12 | |
2-Hydroxyestronec | −78.3 (−84.5, −69.6) | 1.1 × 10−12 | |
2- Hydroxyestradiol | −67.9 (−78.3, −52.6) | 2.7 × 10−7 | |
4-Catechol EMs | |||
4-Hydroxyestrone | −51.8 (−72.9, −14.2) | 0.01 | |
Methylated catechol EM | |||
Methylated 2-catechol EM | −73.5 (−81.2, −62.7) | 1.9 × 10−10 | |
2-Methoxyestrone | −81.2 (−87.1, −72.6) | 1.9 × 10−12 | |
2-Methoxyestradiolc | −62.8 (−78.9, −34.7) | 0.0009 | |
2-Hydroxyestrone-3-methyl etherc | −21.9 (−50.3, 22.6) | 0.28 | |
Methylated 4-catechol EMs | |||
4-Methoxyestrone | NA | NA | |
4-Methoxyestradiol | NA | NA | |
2-Hydroxylation pathway EMs | −74.9 (−81.6, −65.8) | 1.6 × 10−12 | |
4-Hydroxylation pathway EMs | −51.8 (−72.9, −14.2) | 0.01 | |
16-Hydroxylation pathway EMs | 34.7 (1.6, 78.5) | 0.04 | |
16α-Hydroxyestrone | 91.6 (20.2, 205.1) | 0.007 | |
17-Epiestriol | 160.1 (46.0, 363.4) | 0.002 | |
Estriol | 25.5 (−5.1, 66.0) | 0.11 | |
16-Ketoestradiolc | 62.4 (8.7, 142.7) | 0.02 |
Abbreviations: CI=confidence interval; EM=oestrogen metabolite; NA=not available.
Unadjusted analysis.
A negative difference may be interpreted as lower levels in CYP3A7*1C carriers compared with non-carriers.
Missing values: 2-OHE2, 1 sample (non-carrier); 2-MeOE2, 11 samples (11 women, 2 non-carriers, 9 carriers); 3-MeOE1, 11 samples (9 women, 2 non-carriers, 7 carriers), 16-ketoE2, 5 samples (3 women, 2 non-carriers, 1 carrier).