Table 3. Summary of the optimised protocols proposed by the model.

	Etoposide		Cisplatin
Protocol	Time	Dose	Time	Dose
OP1	0–1 h	80 mg m−2	1–2 h	80 mg m−2
	12–84 h	160 mg m−2
OP2 (intensified)	0–1 h	80 mg m−2	1–2 h	80 mg m−2
	12–108 h	300 mg m−2
OP3 (14-day cycle)	0–1 h	40 mg m−2	1–2 h	50 mg m−2
	6–78 h	105 mg m−2