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Increases in IRS-1 lysine acetylation enhance insulin signalling to IRS-1. MCF-7 cells were treated with PMA and/or TSA for 4 hours (concentrations as in Figure 3) prior to stimulation with 100 nM insulin for 10 minutes. IRS-1 was immunoprecipitated and blotted for the presence of phosphotyrosine. The graph summarises results from 3 experiments (± SEM) normalised to the response to insulin stimulation alone.
