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. 2017 Feb 7;7:41929. doi: 10.1038/srep41929

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Left, Predicted scores (tPS) of the Group B- and PD-patients (all treated as unknowns) in the combined OPLS-DA models (peptides and proteins) based on the differences in the AD- and DLB Group A patients. Right, the cross validated scores (tCV) of the combined OPLS-DA models (peptides and proteins) based on all patients. The predictive scores of the PD patients (still treated as unknowns) are also included in the plot. The corresponding ROC-curves of each model are shown below the compared patients. (B) Biomarker selection from the combined patient protein model using Variable Influence in Projection (VIP) values plotted against the p(corr) values. (C) Biomarker selection from the combined patient peptide model using Variable Influence in Projection (VIP) values plotted against the p(corr) values. Loading plots for proteins and peptides that correlated with >99% confidence with each sub-domain are given in Supplementary Table 3.