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. 2017 Feb 7;7:41576. doi: 10.1038/srep41576

Figure 3. Effects of targeted inactivation of Epha3 on mouse intestinal tumorigenesis.

Figure 3

(A,B) Histograms showing the number (A) and size (B) of intestinal tumors in EphA3 wild type and knockout mice at the age of 20 months. (C) Survival of Apcmin/+ mice that are either wild type, heterozygous or homozygous for EphA3 inactivation (n = 20 animals per group). (D) Representative histological image of the normal small intestine, and (E) a representative small intestinal tumor. Samples were stained with hematoxylin and eosin. Scale bar 100 μm. (F,G) Number (F) and size (G) of small intestinal tumors observed in 41-week-old Apcmin/+ mice that are either wild type, heterozygous or homozygous for EphA3 inactivation. (I,J) Number (I) and size (J) of large intestinal tumors observed in 25-week-old wild type or EphA3 knockout mice after azoxymethane (AOM) treatment. N = number of animals per group. All histograms show average values ± SEM. All p-values shown were calculated using Student’s T-test.