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Ultrastructural Studies of the ECM
TEM of the dermis of PI:1 and PIII:1 showed collagen abnormalities with increased interfibrillar space and more variable fibril diameters than did a control sample (top row; scale bars represent 250 nm). Elastic fibers appeared normal in PIII:1 but were very irregular, fragmented, and almost absent in PI:1 (bottom row; scale bars represent 500 nm).
