Table 1.

Type I Error Rate for RV-GDT at α Levels of 0.05 and 0.005

	Discordant Sib-Pair		Affected Sib-Pair		Extended Pedigree		Mixed Family Types
	α = 0.05	α = 0.005	α = 0.05	α = 0.005	α = 0.05	α = 0.005	α = 0.05	α = 0.005
RV-GDT	0.047	0.0048	0.050	0.0051	0.051	0.0049	0.051	0.0048
Each Founder Has a 50% Probability of Missing All Genotype Data
RV-GDT	0.051	0.0050	0.051	0.0049	0.049	0.0047	0.051	0.0047
80% African and 20% European Population Admixture
RV-GDT	0.051	0.0049	0.051	0.0048	0.048	0.0047	0.050	0.0051
50% African and 50% European Families
RV-GDT	0.050	0.0051	0.049	0.0053	0.048	0.0052	0.051	0.0048

We simulated 1,000 families for each pedigree structure shown in Figure 1 and mixed pedigree structures. Genotype data were generated for all autosomal genes across the genome with an OR of 1.0, and type I error rate was defined as the proportion of genes with a p value less than 0.05 or 0.005. We used variant information for 17,987 autosomal genes from the ExAC non-Finnish European population to generate family data when each founder had a 0% or 50% probability of missing genotype data. We used variant information for 17,873 autosomal genes present in both the ExAC non-Finnish European population and African and African American populations to generate family data with population admixture and substructure.