Table 5.

Comparison of Variant Interpretation by CLINVITAE and Automated Interpretation by InterVar

Clinical Significance	InterVar (Automated Interpretation)	CLINVITAE	Concordant
Benign	242	2,407	230
Likely benign	6,593	2,998	2,428
Likely pathogenic	286	106	11
Pathogenic	137	611	132
Uncertain significance	4,438	5,574	3,047
Sum of five tiers	11,696	11,696	5,848
Benign or likely benign	6,835	5,405	4,226
Pathogenic or likely pathogenic	423	717	227