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. 2017 Feb 6;14:30. doi: 10.1186/s12974-017-0804-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Hyperalgesia is modulated by opioid receptor antagonist. The effect of NLXM on the paw withdrawal latency was determined >day 60 after i.a. injections. Data are represented as means ± SEM. Thresholds in ACIA-mice were significantly reduced ipsilaterally at 15 min after NLXM injection as compared to baseline thresholds (Friedman and Dunn’s test, ^§§§ P < 0.001), N = 7–8 mice. No effect was observed in the ipsilateral paw of non-immunized animals or in the contralateral paws of both groups (one-way RM ANOVA and Bonferroni’s multiple comparison test, P > 0.05)