Fig. 6.

CD8⁺-depletion affects serum levels of pro-inflammatory cytokines in arthritic mice. a, b Score for inflammation and destruction in chronic phase of ACIA in CD8⁺-depleted animals or isotype-treated mice. c Serum levels of ACPA- and mBSA-specific IgGs in arthritic mice treated with anti-CD8 or the isotype-matched antibody (left: anti-MCV mutated citrullinated vimentin, right: mBSA). d TNFα and IL-17 levels are elevated in later stages of arthritis in CD8⁺-depleted arthritic mice. Statistical analyses were performed using the Mann-Whitney U test; *P < 0.05, **P < 0.01