Table 2.
Dynamics of RUNX1-RUNX1T1 transcripts post-HSCT in patients in continuous CR
| Month post-HSCT | Number of patients evaluated | Median RUNX1-RUNX1T1 transcript levels (range) | Patients with ≥3-log reduction (%) | Patients with ≥4-log reduction (%) | P value* |
|---|---|---|---|---|---|
| 1 | 174 | 0.011% (0–12.8%) | 163 (93%) | 121 (70%) | <0.0001 |
| 2 | 167 | 0.0062% (0–22.5%) | 160 (96%) | 132 (79%) | <0.0001 |
| 3 | 161 | 0 (0–17.8%) | 153 (95%) | 127 (79%) | <0.0001 |
| 4.5 | 126 | 0 (0–1.5%) | 122 (97%) | 93 (74%) | <0.0001 |
| 6 | 143 | 0 (0–2.4%) | 139 (97%) | 123 (86%) | 0.001 |
| 9 | 113 | 0 (0–4.1%) | 111 (98%) | 99 (88%) | 0.003 |
| 12 | 118 | 0 (0–0.66%) | 116 (98%) | 110 (93%) | 0.10 |
| 18 | 90 | 0 (0–0.30%) | 90 (100%) | 87 (97%) | 0.25 |
| 24 | 72 | 0 (0–0.30%) | 72 (100%) | 68 (94%) | 0.12 |
| 30 | 23 | 0 (0–0.49%) | 22 (96%) | 22 (96%) | 1.0 |
| 36 | 27 | 0 (0–0.005%) | 27 (100%) | 27 (100%) | 1.0 |
*Comparison of the frequency of patients with a ≥3-log reduction with the frequency of patients with a ≥4-log reduction at each time point