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. 2017 Feb;214(2):459–473. doi: 10.1084/jem.20160592

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© 2017 Lang et al.

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Figure 10. — TRIM65 is critical for EMCV-induced MDA5 signaling activation in vivo. (A) Concentration of IFN-β in serum from age- and sex-matched WT (n = 6) or Trim65^−/− (n = 9) mice inoculated intravenously with EMCV, assessed 12 h after infection. (B) Concentration of IFN-α in serum from age- and sex-matched WT (n = 8) or Trim65^−/− (n = 9) mice inoculated intravenously with EMCV, assessed 12 h after infection. (C) Survival analysis of age- and sex-matched WT (n = 9) or Trim65^−/− (n = 7) mice inoculated intravenously with EMCV for 6 d. (D) Histological analysis of pancreas sections from WT or Trim65^−/− mice infected with EMCV for 48 h. Bar, 100 µm. (E) qPCR analysis of EMCV RNA in pancreas of WT (n = 8) or Trim65^−/− (n = 9) mice infected with EMCV for 48 h. (F) Concentration of IFN-β in serum from age- and sex-matched WT (n = 7) or Trim65^−/− (n = 7) mice inoculated intravenously with VSV, assessed 12 h after infection. (G) qPCR analysis of VSV RNA in pancreas of WT (n = 5) or Trim65^−/− (n = 5) mice infected with VSV for 24 h. Data are from two or three independent experiments (A, B, and E–G; mean and SEM). Statistics were analyzed via an unpaired Students’ t test (A, B, and E–G) or a generalized Wilcoxon test (C): **, P < 0.01; ***, P < 0.001.