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. 2004 Dec 1;114(11):1586–1592. doi: 10.1172/JCI22715

Figure 2.

Figure 2

TGF-β activity and signaling in mitral valves of fibrillin-1–;deficient mice. Immunohistochemical analysis using antibodies specific to free and active TGF-β (LC1-30), LAP-β1, and P-Smad2 in wild-type (Fbn1+/+) mice and littermates either heterozygous (Fbn1+/–;) or homozygous (Fbn1–;/–;) for mutation C1039G. Mutant valves show increased TGF-β activity and signaling but not increased expression of LAP-β1, indicative of increased TGF-β activation rather than cytokine production. Magnification, ×100. Scale bars: 20 μm.