Table 2.
Neurovirulence of the mutated viruses in 3-week-old mice inoculated by the i.c. route.
| Viruses | LD50 (log10PFU) * | |
|---|---|---|
| rJEV (SA14-14-2) | ≥6.48 | |
| rJEV1 (E107) | 3.97 | |
| rJEV2 (E138) | 2.89 | |
| rJEV3 (E176/E177) | ≥6.43 | |
| rJEV4 (E279) † | ≥6.24 | |
| rJEV5 (E107/E138) | 1.70 | |
| rJEV6 (E107/E176/E177) | 5.69 | |
| rJEV7 (E138/E176/E177) | 3.64 | |
| rJEV8 (E138/E279) | 2.82 | |
| rJEV9 (E107/E138/E176/E177) | 1.99 | |
| rJEV10 (E107/E138/E176/E177/E279) | 1.43 | |
| rJEV11/SA14 | 0.66 | |
| SA14 | −0.92 | |
* LD50 (log10PFU) represents the plaque titers that cause death in 50% of tested mice; † Virus rJEV4 did not cause neurovirulence.