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. 2017 Jan 6;8(1):20. doi: 10.3390/genes8010020

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© 2017 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Repriming roles of PrimPol in nuclear DNA replication. PrimPol is able to reprime and reinitiate leading strand replication downstream of a range of replicase stalling obstacles. Here, the ability of PrimPol to reprime downstream of DNA lesions, G4 secondary structures, and chain-terminating nucleotide analogues, is highlighted. Following repriming, replication can proceed and the resulting single-stranded DNA (ssDNA) gap is filled through translesion synthesis (TLS) or template switching mechanisms, permitting subsequent repair or removal of the obstacle. Only the CDC45, MCM, GINS (CMG) complex, Pol ε, PrimPol, and RPA, are shown for simplicity. A key for identifying each factor is shown below. CTNA: chain-terminating nucleoside analogues.