Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In E. coli, the initiator DnaA forms a helical oligomer during initiation which associates with the upper strand of the ssDNA. Following unwinding of the DUE, interactions between DnaA and DnaB or DnaC in the DnaC–DnaB complex are thought to correctly orientate DnaB for loading onto the bottom and top strands of DNA, respectively. Figure adapted from [88].
