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. 2017 Jan 11;8(1):26. doi: 10.3390/genes8010026

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© 2017 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The origin of replication in Escherichia coli, oriC. This 245-bp sequence consists of the 13-mer DNA unwinding element (red), DnaA-trio motifs (blue), and binding sites for DnaA, Integration Host Factor (IHF), and Fis. Additionally, flanking genes gidA and mioC are shown. The arrows represent the transcription direction of the flanking genes (large, hollow arrows) and directionality of DnaA filament formation (small arrows above DnaA boxes). The black arrows help visualize each type of supercoiling, shown above the oriC.