Table 3.
Sputum mRNA gene expression at baseline, 4 h, and fold change at 4 h following soluble fibre or control meal challenge ^.
Gene | Soluble Fibre Group (n = 8) | p † | Control Group (n = 4) | p † | p * | ||||
---|---|---|---|---|---|---|---|---|---|
0 h | 4 h | FC | 0 h | 4 h | FC | ||||
GPR43 | 0.07 [0.05, 0.29] | 0.79 [0.26, 2.01] | 6.26 [1.66, 13.5] | 0.124 | 1.53 [0.29, 3.64] | 0.24 [0.17, 0.27] | 0.31 [0.07, 0.67] | 0.068 | 0.007 |
GPR41 | 0.07 [0.04, 0.35] | 1.70 [0.14, 5.18] | 5.15 [3.96, 22.9] | 0.161 | 1.27 [0.80, 1.42] | 0.58 [0.41, 1.22] | 0.41 [0.31, 2.37] | 0.715 | 0.027 |
GPR: G protein-coupled receptor; FC: fold change. ^ Data are nonparametric, presented as median [quartile 1, quartile 3], within-group changes analyzed by Wilcoxon matched pairs signed-rank test and group comparison performed using Wilcoxon rank-sum test. † Difference in change from 0 to 4 h within group. * Difference in fold change between the soluble fibre and control group.