Table 3.
List of potential serum biomarkers in mice fed a High-Fat Diet (HFD) including 5% Platycodon grandiflorum using various MS analyses.
| No. | Metabolite | Fold Change 1 | ||
|---|---|---|---|---|
| HFD/ND | HPGL/HFD | HPGH/HFD | ||
| 1 | Ornithine | 1.38 # | 0.76 # | 0.72 # |
| 2 | Tryptophan | 1.26 # | 0.85 # | 0.78 # |
| 3 | Saccharide * | 1.67 # | 0.92 | 0.79 # |
| 4 | LysoPC 20:4 | 1.65 # | 0.98 | 0.66 # |
| 5 | PC 34:2 (16:0/18:2) | 0.55 # | 0.88 | 1.39 # |
| 6 | PC 36:4 (16:0/20:4) | 1.50 # | 1.11 | 0.71 # |
| 7 | PC 38:4 (18:0/20:4) | 2.28 # | 1.01 | 0.60 # |
| 8 | PC 38:3 (18:0/20:3) | 2.07 # | 1.00 | 0.65 # |
| 9 | PC 38:3 | 1.29 # | 1.07 | 0.77 # |
| 10 | TG 52:3 | 0.53 # | 0.66 | 2.06 # |
ND, group fed with a normal diet; HFD, group fed with a high-fat diet; HPGL, group fed with a high-fat diet and 1% P. grandiflorum; HPGH, group fed with a high-fat diet and 5% P. grandiflorum. 1 Fold change was calculated by dividing the mean of the peak intensity of each metabolite from each of the two groups. * Saccharide was not successfully identified, but its mass fragments were similar to general mass fragments of saccharides in GC-TOF-MS analysis. # Metabolites showing significant differences (p < 0.05) between groups as determined by Student’s t-test.