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. 2017 Jan 23;9(1):87. doi: 10.3390/nu9010087

Figure 3.

Figure 3

Overcoming chemoresistance with 1,25(OH)2D3. Through genomic or non-genomic mechanisms, 1,25(OH)2D3 may affect the various players involved in mediating resistance to chemotherapeutics, such as modulating tumor microenvironment, cancer stem cell signaling, as well as drug influx, efflux, and metabolism.