Table 2.
Baseline characteristics comparing high-risk non-alcoholic steatohepatitis to low-risk non-alcoholic steatohepatitis recipients
| High-risk NASH (n = 465) | Low-risk NASH (n = 2775) | P value | |
| Recipient characteristics | |||
| Age at listing, mean years (95%CI) | 64.0 (63.8-64.3) | 56.7 (56.2-56.9) | < 0.001 |
| Age at transplant, mean years (95%CI) | 64.5 (64.2-64.7) | 57.0 (56.8-57.4) | < 0.001 |
| Male gender | 247 (52.4) | 1500 (53.0) | NS |
| African American race | 7 (0.2) | 58 (1.6) | NS |
| Hispanic race | 43 (9.1) | 305 (10.8) | NS |
| BMI at transplant, kg/m2, mean (95%CI) | 35.1 (34.7-35.5) | 31.8 (31.5-32.0) | < 0.001 |
| Portal vein thrombosis | 66 (14.2) | 326 (11.8) | NS |
| Severity of liver disease | |||
| MELD score at listing, mean (95%CI) | 19.5 (18.7-20.3) | 20.1 (19.8-20.4) | NS |
| MELD score at transplantation, mean (95%CI) | 22.8 (21.9-23.6) | 23.7 (23.3-24.0) | NS |
| Laboratory values | |||
| Serum bilirubin, mg/dL, mean (95%CI) | 6.2 (5.4-7.0) | 7.7 (7.3-8.0) | 0.002 |
| INR, mean (95%CI) | 1.81 (1.75-1.86) | 1.94 (1.91-1.97) | 0.002 |
| Serum albumin, g/dL, mean (95%CI) | 3.1 (3.0-3.2) | 3.0 (2.9-3.1) | 0.006 |
| Creatinine, g/dL, mean (95%CI) | 1.98 (1.85-2.11) | 1.78 (1.73-1.83) | 0.003 |
| On dialysis at transplantation | 73 (15.5) | 415 (14.7) | NS |
| Portal hypertension manifestations | |||
| Moderate-severe ascites at transplant | 178 (37.8) | 1032 (36.5) | NS |
| Moderate-severe hepatic encephalopathy at transplant | 51 (10.8) | 324 (11.5) | NS |
HR-NASH recipients were older, had higher BMI values and were more likely to have renal dysfunction. BMI: Body mass index; HR: High-risk; NASH: Non-alcoholic steatohepatitis; NS: Not significant; INR: International normalized ratio.