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Surface interactions affect the toxicity of metal oxide NPs toward Paramecium: (a) survival ratios of P. multimicronucleatum after 48 h of exposure to NPs; (b) net interaction energy profiles between NPs and P. multimicronucleatum; (c) relationship of the magnitude of energy barrier and the 48-h LC50 of metal oxide NPs to P. multimicronucleatum (reproduced with permission from [213], Copyright American Chemical Society, 2012)
