Table 1.
Demographic profile and clinical characteristics of the study subjects
| Original cohort | Validation cohort | Twin cohort | |||||
|---|---|---|---|---|---|---|---|
| ART (n = 182) | Controls (n = 77) | P value | ART (n = 55) | Controls (n = 57) | P value | ART (n = 39 pairs) | |
| Maternal age (years, mean ± SD) | 34.7 ± 3.6 | 32.2 ± 4.8 | < 0.0001 a | 35.8 ± 3.9 | 29.5 ± 6.1 | < 0.0001 a | 37.2 ± 5.2 |
| Paternal age (years, mean ± SD) | 36.9 ± 5.7 | 33.3 ± 5.2 | < 0.0001 a | 38.3 ± 6.5 | 34.8 ± 4.6 | 0.0610 | 39.0 ± 6.9 |
| Mode of egg fertilization (ICSI/non ICSI) | 54/127 | NA | – | 30/23 | NA | – | 14/24 |
| Oxygen tension (20/5%) | 123/59 | NA | – | 16/38 | NA | – | 19/19 |
| Type of embryo transfer (fresh/frozen) | 128/54 | NA | – | 33/22 | NA | – | 26/13 |
| Embryo transfer day (day 3/day 5) | 110/72 | NA | – | 17/37 | NA | – | 18/20 |
| Gestational age (weeks, mean ± SD) | 39.2 ± 1.3 | 39.1 ± 1.2 | 0.4306a | 38.2 ± 3.6 | 38.2 ± 6.4 | 0.9990a | 36.5 ± 2.1 |
| Birth weight (grams, mean ± SD) | 3441.5 ± 498.6 | 3318.8 ± 559.3 | 0.0837a | 3196 ± 918.4 | 3411 ± 541.7 | 0.1324a | 2653.1 ± 576.9 |
| Males (%) | 83(45.6) | 39 (50.6) | 0.4972b | 26 | 29 | 0.7103b | 39(50.0) |
| Females (%) | 99(54.4) | 38 (49.4) | 29 | 28 | 39(50.0) | ||
ART assisted reproductive technology; SD standard deviation;
ICSI intracytoplasmic sperm injection; NA not applicable
aUnpaired two-tailed t test
bFisher’s exact test
Values in italics denote significance