Table 2.
Genotype frequencies of miR-SNPs in lead-sensitive and lead-resistant participants.
| Genotype | Lead-Sensitive (n = 113) | Lead-Resistant (n = 113) | HWE | p * | Adjusted OR (95% CI) * | ||
|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||
| DICER | |||||||
| rs3742330 | 0.430 | ||||||
| AA | 47 | 41.6 | 51 | 45.1 | 1.00 (Ref.) | ||
| AG | 46 | 40.7 | 47 | 41.6 | 0.957 | 0.98 (0.55–1.77) | |
| GG | 20 | 17.7 | 15 | 13.3 | 0.385 | 1.43 (0.64–3.18) | |
| A allele | 140 | 61.9 | 149 | 65.9 | 1.00 (Ref.) | ||
| G allele | 86 | 38.1 | 77 | 34.1 | 0.488 | 1.14 (0.78–1.66) | |
| XPO5 | |||||||
| rs2257082 | 0.543 | ||||||
| TT | 32 | 28.3 | 47 | 41.6 | 1.00 (Ref.) | ||
| CT | 62 | 54.9 | 54 | 47.8 | 0.096 | 1.68 (0.91–3.10) | |
| CC | 19 | 16.8 | 12 | 10.6 | 0.034 | 2.60 (1.08–6.28) | |
| CT/CC | 81 | 71.7 | 66 | 58.4 | 0.038 | 1.85 (1.03–3.32) | |
| TT/CT | 94 | 83.2 | 101 | 89.4 | 1.00 (Ref.) | ||
| CC | 19 | 16.8 | 12 | 10.6 | 0.112 | 1.92 (0.86–4.30) | |
| T allele | 126 | 55.8 | 148 | 65.5 | 1.00 (Ref.) | ||
| C allele | 100 | 44.2 | 78 | 34.5 | 0.022 | 1.63 (1.07–2.47) | |
| DROSHA | |||||||
| rs10719 | 0.104 | ||||||
| TT | 90 | 79.6 | 83 | 73.4 | 1.00 (Ref.) | ||
| CT | 23 | 20.4 | 30 | 26.6 | 0.563 | 0.83 (0.43–1.66) | |
| CC | 0 | 0.0 | 0 | 0.0 | - | - | |
| T allele | 203 | 89.8 | 196 | 86.7 | 1.00 (Ref.) | ||
| C allele | 23 | 10.2 | 30 | 13.3 | 0.563 | 0.83 (0.43–1.66) | |
| RAN | |||||||
| rs14035 | 0.080 | ||||||
| CC | 65 | 57.5 | 81 | 71.7 | 1.00 (Ref.) | ||
| CT | 48 | 42.5 | 32 | 38.3 | 0.061 | 1.73 (0.98–3.08) | |
| TT | 0 | 0.0 | 0 | 0.0 | - | - | |
| C allele | 178 | 78.8 | 194 | 85.8 | 1.00 (Ref.) | ||
| T allele | 48 | 21.2 | 32 | 14.2 | 0.061 | 1.73 (0.98–3.08) | |
| GEMIN4 | |||||||
| rs910924 | 0.207 | ||||||
| CC | 82 | 72.6 | 89 | 78.8 | 1.00 (Ref.) | ||
| CT | 31 | 27.4 | 24 | 21.2 | 0.235 | 1.47 (0.78–2.78) | |
| TT | 0 | 0.0 | 0 | 0.0 | - | - | |
| C allele | 195 | 86.3 | 202 | 89.4 | 1.00 (Ref.) | ||
| T allele | 31 | 13.7 | 24 | 10.6 | 0.235 | 1.47 (0.78–2.78) | |
| rs4968104 | 0.118 | ||||||
| TT | 80 | 70.8 | 84 | 74.3 | 1.00 (Ref.) | ||
| AT | 33 | 29.2 | 29 | 25.7 | 0.663 | 1.14 (0.63–2.08) | |
| AA | 0 | 0.0 | 0 | 0.0 | - | - | |
| T allele | 193 | 85.4 | 197 | 87.2 | 1.00 (Ref.) | ||
| A allele | 33 | 14.6 | 29 | 12.8 | 0.663 | 1.14 (0.63–2.08) | |
| rs2740348 | 0.338 | ||||||
| CC | 80 | 70.8 | 87 | 77.0 | 1.00 (Ref.) | ||
| CG | 26 | 23.0 | 23 | 20.4 | 0.602 | 1.20 (0.61–2.33) | |
| GG | 7 | 6.2 | 3 | 2.6 | 0.238 | 2.36 (0.57–9.82) | |
| C allele | 186 | 82.3 | 197 | 87.2 | 1.00 (Ref.) | ||
| G allele | 40 | 17.7 | 29 | 12.8 | 0.246 | 1.35 (0.81–2.23) | |
* Adjusted for sex, age, smoking, and education, drinking, and eating habit in workplace. DICER: dicer 1 ribonuclease III; XPO5: exportin 5; DROSHA: drosha ribonuclease III; GEMIN4: gem nuclear organelle associated protein 4.