Table 2.
Meta-prediction: Air Pollution Levels and MTHFR C677T Polymorphism Genotypes for Controls (ct) and Alzheimer’s Disease (AD) Cases (ca), and AD Risks.
| Partition Tree | Tukey’s Test | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | AICc | AP Death Levels | Count | Mean | SD | Levels Compared | Difference | SE Difference | Lower CI | Upper CI | p |
| TT%ct | 318.732 | 2 | 11 | 8.182 | 7.427 | 4/2 | 7.874 | 3.319 | −0.198 | 15.945 | 0.0572 |
| 3 and 4 | 33 | 15.364 | 8.930 | 3/2 | 6.3515 | 3.443 | −2.021 | 14.724 | 0.1680 | ||
| 4/3 | 1.5222 | 3.032 | −5.851 | 8.896 | 0.8707 | ||||||
| TT%ca | 308.987 | 2 | 11 | 7.091 | 4.549 | 3/2 | 11.042 | 3.089 | 3.731 | 18.753 | 0.0021 |
| 4 and 3 | 33 | 17.939 | 8.441 | 4/2 | 10.520 | 2.978 | 3.279 | 17.762 | 0.0029 | ||
| 3/4 | 0.722 | 2.720 | −5.893 | 7.337 | 0.9619 | ||||||
| CT%ct | 317.809 | 2 | 11 | 34.273 | 10.762 | 3/2 | 9.661 | 3.407 | 1.377 | 17.944 | 0.0190 |
| 4 and 3 | 33 | 43.091 | 7.666 | 4/2 | 8.116 | 3.284 | 0.130 | 16.102 | 0.0457 | ||
| 3/4 | 1.544 | 3.000 | −5.751 | 8.840 | 0.8646 | ||||||
| CT%ca | 339.208 | 2 and 3 | 26 | 46.115 | 11.389 | 4/2 | 3.096 | 4.195 | −7.104 | 13.296 | 0.7425 |
| 4 | 18 | 48.278 | 9.999 | 3/2 | 1.618 | 4.351 | −8.962 | 12.198 | 0.9267 | ||
| 4/3 | 1.478 | 3.832 | −7.840 | 10.796 | 0.9214 | ||||||
| CC%ct | 366.743 | 3 and 4 | 33 | 41.576 | 14.331 | 2/3 | 16.055 | 5.959 | 1.564 | 30.545 | 0.0269 |
| 2 | 11 | 57.455 | 16.336 | 2/4 | 15.732 | 5.745 | 1.762 | 29.703 | 0.0242 | ||
| 4/3 | 0.322 | 5.248 | −12.440 | 13.084 | 0.9979 | ||||||
| CC%ca | 364.011 | 4 and 3 | 33 | 34.545 | 12.696 | 2/4 | 13.616 | 5.567 | 0.078 | 27.154 | 0.0484 |
| 2 | 11 | 47.727 | 18.778 | 2/3 | 12.661 | 5.775 | −1.382 | 26.703 | 0.0845 | ||
| 3/4 | 0.956 | 5.086 | −11.412 | 13.323 | 0.9807 | ||||||
| RRTT | 118.544 | 2 | 11 | 1.073 | 1.016 | 4/2 | 0.377 | 0.342 | −0.455 | 1.209 | 0.5180 |
| 3 and 4 | 33 | 1.424 | 0.838 | 3/2 | 0.321 | 0.355 | −0.542 | 1.184 | 0.6413 | ||
| 4/3 | 0.057 | 0.313 | −0.703 | 0.817 | 0.9821 | ||||||
| RRCT | 7.777 | 3 and 4 | 33 | 1.124 | 0.206 | 2/3 | 0.250 | 0.100 | 0.006 | 0.493 | 0.0433 |
| 2 | 11 | 1.336 | 0.359 | 2/4 | 0.181 | 0.097 | −0.054 | 0.415 | 0.1593 | ||
| 4/3 | 0.069 | 0.088 | −0.145 | 0.283 | 0.7164 | ||||||
| RRCC | −21.842 | 2 and 4 | 29 | 0.822 | 0.185 | 3/2 | 0.026 | 0.072 | −0.149 | 0.201 | 0.9299 |
| 3 | 15 | 0.848 | 0.167 | 3/4 | 0.026 | 0.063 | −0.128 | 0.180 | 0.9132 | ||
| 4/2 | 0.0004 | 0.069 | −0.168 | 0.169 | 1.0000 | ||||||
Note. MTHFR = methylenetetrahydrofolate reductase; CI = confidence interval; AICc = Akaike’s information criterion correction; AP Death Levels = annual death rates from air pollution levels per million population (Levels 2 = 50–100, 3 = 100–250, 4 = 250–400 and greater); RR = Risk Ratio; ct = controls; ca = AD cases; TT%ct = percentages of MTHFRC677T TT genotype in control group; TT%ca = percentages of TT genotype in AD cases; CT%ct = percentages of CT genotype in control group; CT%ca = percentages of CT genotype in AD cases; CC%ct = percentages of CC wildtype in control group; CC%ca = percentages of CC wildtype in AD cases; RRTT = risk ratio of TT; RRCT = risk ratio of CT; RRCC = risk ratio of CC.