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. 2016 Aug 15;7(36):57498–57513. doi: 10.18632/oncotarget.11292

Figure 4. KB upregulates ASGPR in hepatocytes and mouse liver tissues.

Figure 4

A. Murine primary hepatocytes were untreated (NC) or treated with LPS (1 μg/ml), KB (15 μM) or LPS preincubated with KB for 4 h. Real-time PCR was used to detect ASGPR, MARCO, SR-A, SR-B1, TFRC and LOX-1 expression. *P < 0.05, **P < 0.01 vs. NC. B. & C. Primary hepatocytes isolated from WT C57BL/6 mice were untreated (NC) or treated with KB (15 μM) for 1, 2 or 4 h. ASGPR expression was detected by immunofluorescence B. or immunoblotting C. D. C57 BL/6 mice were injected with NS or KB (3.6 mg/kg) for 1, 2 or 4 h. ASGPR expression in liver homogenates as detected by immunoblotting, with tubulin as an internal control.