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. 2016 Aug 15;7(36):57498–57513. doi: 10.18632/oncotarget.11292

Figure 8. KB directly binds and inhibits LPS while GalNAc does not.

Figure 8

A. Binding of KB (1.5 mM) and GalNAc (1.5 mM) with lipid A, the active center of LPS, was examined by bio-sensor. B. LPS (1 ng/ml) neutralization by GalNAc (4.5 μM) or KB (4.5 μM) was examined by limulus test. *P < 0.05. C. RAW 264.7 cells were incubated with LPS (100 ng/ml) alone or with KB (100 μM) or GalNAc (100 μM) for 4 h. TNF-α levels in the supernatant were examined by ELISA. *P < 0.05 vs LPS. D. C57 BL/6 mice were injected with sterile NS or LPS (1 mg/kg) preincubated with NS, KB (3.6 mg/kg), GalNAc (100 mg/kg) or KB+ GalNAc. TNF-α levels in blood and liver tissues were examined at 4 h. *P < 0.05, **P < 0.01.