Table 1. Characteristics of studies included in pooling ORs analysis.
| Author | Year | Country | Cancer Type | Control Source | Study Design | Detection Assay | NOS Score | Case/Control | Adjusted OR (95% CI) | Adjustments |
|---|---|---|---|---|---|---|---|---|---|---|
| Alokail | 2013 | Saudi Arabia | BC | HB | Retrospective case-control | ELISA | 6 | 56/53 | 1.90 (0.62-5.70) | age, menopausal status of menarche |
| Aly | 2013 | Egypt | BC | HB | Retrospective case-control | ELISA | 5 | 35/40 | 1.26(1.21-1.93) | No |
| Dalamaga | 2013 | Greece | BC | HB | Retrospective case-control | ELISA | 6 | 102/102 | 1.17(1.03-1.34) | age, date of diagnosis, education, BMI, waist circumference, family history of cancer, use of exogenous hormones, smoking history, adiponectin and leptin concentration, inflammatory markers, alcohol consumption, smoking status |
| Danese | 2012 | Italy | CC | HB | Retrospective case-control | ELISA | 6 | 40/40 | 1.33(1.03-1.72) | age, sex, BMI, lifestyle parameters |
| Gaudet1 | 2010 | United States | BC | PB | Prospective nest case-control | Human Adipokine Panel | 7 | 234/231 | 1.09(0.58-2.08) | age, BMI, number of births, age at first full-term birth, age at menopause, and current postmenopausal hormone use |
| Gunter1 | 2015 | United States | BC | PB | Prospective case-cohort | Human Adipokine Panel | 6 | 875/820 | 1.00(0.81-1.22) | age, ethnicity, alcohol consumption, family history of breast cancer, parity, year of menstrual cycling, age at first child's birth, use of hormone therapy, endogenous estradiol levels, history of benign breast disease, BMI and physical activity |
| Ho1 | 2012 | United States | CC | PB | Prospective case-cohort | Human Adipokine Panel | 6 | 427/797 | 0.89(0.58-1.38) | age, race, smoking status, ever had colonoscopy, estrogen level, insulin, waist circumference |
| Hou | 2007 | China | BC | HB | Retrospective case-control | ELISA | 6 | 80/50 | 1.34(1.11-2.35) | NA |
| Kang | 2007 | Korea | BC | HB | Retrospective case-control | ELISA | 6 | 41/43 | 2.77(1.40-5.50) | age, BMI, status of menopause, serum glucose and adiponectin |
| Liao1 | 2012 | Finland | RCC | PB | Prospective nest case-control | ELISA | 8 | 273/273 | 1.15(0.80-1.51) | number of years smoking, presence of hypertension, history of diabetes and physical activity |
| Nakajima | 2010 | Japan | CC | HB | Retrospective case-control | ELISA | 7 | 115/115 | 2.07(1.05-4.06) | NA |
| Otake | 2010 | Japan | CC | HB | Retrospective case-control | ELISA | 5 | 98/26 | 0.88(0.16-1.60) | No |
| Sun1 | 2010 | Taiwan | BC | HB | Retrospective case-control | ELISA | 7 | 380/760 | 1.77(0.90-2.64) | age, waist circumference, hormone replacement therapy use, family history of breast cancer, age at enrollment, age at menarche, age at first full-term pregnancy, parity number |
1
Risk estimates were recalculated by the method proposed by Harmling et al.
Abbreviations: HB= Hospital Based; PB = Population Based; OR = Odds Ratio; CI = Confidence Interval; ELISA = Enzyme-linked Immunosorbent Assay; BMI = Body Mass Index; NA = Unknown; NOS = Newcastle-Ottawa Scale; BC = Breast Cancer; CC = Colorectal Cancer; RCC = Renal Cell Cancer.