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. 2016 Aug 5;7(36):57821–57831. doi: 10.18632/oncotarget.11067

Figure 1. Relationship between UHRF1 expression and LINE-1 methylation levels in ESCC tissues.

Figure 1

(A) UHRF1 mRNA expression levels in esophageal cancers and matched normal mucosa (N = 16). The cancer tissues showed significantly higher levels of expression than the matched normal mucosa (P < 0.0001 by paired t-test). (B) UHRF1 immunostaining of esophageal cancer and normal esophageal mucosa. (a) Cancerous lesions show positive staining whereas normal mucosa shows negative staining. (b) Positive expression of UHRF1 in nuclei of esophageal cancer cells. (c) Negative expression of UHRF1 in nuclei of esophageal cancer cells. (C) UHRF1 mRNA expression levels were negatively associated with LINE-1 methylation levels (P = 0.0044). (D) UHRF1-positive tumors showed significantly lower levels of LINE-1 methylation than UHRF1-negative tumors (P = 0.00080 by paired t-test).