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. 2016 Jul 22;7(36):57932–57942. doi: 10.18632/oncotarget.10773

Figure 3. ZOL retards U87 xenografts growth in vivo.

Figure 3

A. U87 tumors were implanted subcutaneously in flanks of NSG mice; mice were treated with 0.2 mg/kg ZOL 5 times /week about 3 weeks. Tumor size decreased after ZOL treatment; at day 31 the average size is 567.8±114.3mm3 vs. 178.3±50.4mm3 in vehicle-treated mice (n=12, P<0.01). B. Tumor weight was significantly lower following ZOL treatment; the average weight of ZOL-treated tumors was 0.60±0.26g vs. 0.18±0.21g in controls (n=12, P<0.001). C. Ki67 staining showed less proliferation cell in tumor after ZOL treatments.