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This cartoon depicts the sites of action of ZOL and statins targeting the mevalonate synthesis pathway. The intermediates in this pathway, FPP and GGPP also modify Ras and Rab proteins. The prenyltransferases include FTase, GGTase-1 and RabGGTase: FTase encoded by FNTA and FNTB gene, GGTase-1 encoded by FNTA and PGGT1B, and RabGGTase encoded by RabGGTA and RabGGTB.
