Table 1. Genotype frequencies of DcR3 polymorphisms and their associations with breast cancer risk.
| SNP | Minor, (a) | Major, (A) | Cases (%) | Controls (%) | P value for model of inheritance | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ‘AA’ | ‘Aa’ | ‘aa’ | ‘AA’ | ‘Aa’ | ‘aa’ | Additive | Dominant | Recessive | |||
| Rs3208008 | C | A | 249 (47.52%) |
226 (43.13%) |
49 (9.35%) |
285 (48.80%) |
248 (42.47%) |
51 (8.73%) |
0.887 | 0.670 | 0.720 |
| Rs41309931 | T | G | 298 (57.09%) |
189 (36.21%) |
35 (6.70%) |
269 (46.54%) |
259 (44.81%) |
50 (8.65%) |
0.002 | 0.0005label# | 0.228 |
| Rs2297441 | A | G | 259 (49.81%) |
226 (43.46%) |
35 (6.73%) |
267 (46.11%) |
266 (45.94%) |
46 (7.95%) |
0.426 | 0.221 | 0.442 |
| Rs1291207 | G | A | 263 (50.29%) |
203 (38.81%) |
57 (10.90%) |
270 (46.39%) |
249 (42.78%) |
63 (10.83%) |
0.381 | 0.196 | 0.969 |
Rs3208008 cases n = 524, missing n = 7; controls n = 584, missing n = 8.
Rs41309931 cases n = 522, missing n = 9; controls n = 578, missing n = 14.
Rs2297441 cases n = 520, missing n = 11; controls n = 579, missing n = 13.
Rs1291207 cases n = 523, missing n = 8; controls n = 582, missing n = 10.
Minor allele ‘a’ and the major ‘A’ are shown in the table. ‘AA’, ‘Aa’, ‘aa’ represent a given variant for each SNP genotyped. Numbers in the columns marked “cases” and “controls” are the numbers of each class of genotype. Significant values (p < 0.05) are in bold.
#
Continuity correction P value 0.001.