Table 3. Cox regression analysis of SNHG1 with established risk factors in GSE62564 NB cohort (n= 493).
| Variables | EFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Univariate model | ||||||
| MYCN (amp vs non-amp) | 3.22 | (2.35–4.41) | 3.19E-13 | 7.80 | (5.27–11.55) | < 2e-16 |
| Stage (4 vs 1,2,3 & 4S) | 3.88 | (2.86–5.27) | < 2e-16 | 8.56 | (5.38–13.63) | < 2e-16 |
| Age (≥ 18 months vs < 18 months) | 3.33 | (2.46–4.52) | 9.88E-15 | 8.55 | (5.24–13.94) | < 2e-16 |
| Age (cont.) | 1.00 | (1–1) | 5.32E-13 | 1.00 | (1–1) | 3.22E-15 |
| Sex (male vs female) | 0.90 | (0.69–1.19) | 4.69E-01 | 0.94 | (0.65–1.36) | 7.46E-01 |
| SNHG1 (≥ 5.65 vs < 5.65) | 3.03 | (2.2–4.18) | 1.09E-11 | 6.54 | (3.93–10.89) | 5.25E-13 |
| SNHG1 (cont.) | 1.76 | (1.53–2.02) | 1.78E-15 | 2.37 | (1.99–2.81) | < 2e-16 |
| TAF1D (≥ 4.11 vs < 4.11) | 1.62 | (1.2–2.17) | 1.55E-03 | 1.89 | (1.27–2.8) | 1.69E-03 |
| TAF1D (cont.) | 1.58 | (1.32–1.89) | 5.11E-07 | 2.10 | (1.69–2.62) | 2.50E-11 |
| Multivariate model | ||||||
|---|---|---|---|---|---|---|
| MYCN (amp vs non-amp) | 1.34 | (0.9–2.01) | 1.51E-01 | 2.80 | (1.65–4.75) | 1.34E-04 |
| SNHG1 (≥ 5.65 vs < 5.65) | 1.58 | (1.06–2.35) | 2.36E-02 | 2.22 | (1.21–4.07) | 1.02E-02 |
| TAF1D (≥ 4.11 vs < 4.11) | 1.24 | (0.87–1.77) | 2.36E-01 | 0.93 | (0.56–1.54) | 7.67E-01 |
| Stage (4 vs 1,2,3 & 4S) | 2.10 | (1.43–3.09) | 1.68E-04 | 2.63 | (1.51–4.56) | 6.05E-04 |
| Age (≥ 18 months vs < 18 months) | 1.97 | (1.39–2.8) | 1.60E-04 | 3.54 | (2.04–6.12) | 6.60E-06 |
| MYCN (amp vs non-amp) | 1.85 | (1.08–3.17) | 2.57E-02 | 5.19 | (2.72–9.93) | 6.34E-07 |
| SNHG1 (cont.) | 1.72 | (1.33–2.24) | 4.35E-05 | 1.95 | (1.38–2.77) | 1.68E-04 |
| TAF1D (cont.) | 0.76 | (0.58–0.99) | 4.15E-02 | 0.59 | (0.43–0.83) | 1.89E-03 |
Abbreviations: EFS = event-free survival; OS = overall survival; HR = hazard ratio; CI = confidence interval; P = P-value; cont. = continuous expression.
a
In both univariate and multivariate Cox regression analyses, the gene median expression cutoff was used to divide patients into high and low expression groups.
b
P-value in bold typeface indicates statistical significance (P < 0.05).