Figure 8. Sensitivity of SHEP and its sub-line with acquired resistance to SNS-032 (SHEP^rSNS-032^2000nM) to the non-ABCB1 substrates cisplatin, seliciclib (CDK2, 7, and 9 inhibitor), LDC000067 (CDK7 inhibitor), and BS-181 (CDK9 inhibitor).

(A) Fold change IC₅₀ SHEP^rSNS-032^2000nM/ IC₅₀ SHEP; numerical values are presented in Supplementary Table S1K. (B) Effects of SNS-032 or actinomycin D (100 ng/mL) (interferes with RNA polymerase activity through DNA intercalation independently of CDK7 and CDK9) on RNA polymerase activity in SHEP and SHEP^rSNS-032^2000nM cells in the absence or presence of the ABCB1 inhibitor verapamil (10 μM) as determined after 6 h of incubation. Numerical values are presented in Supplementary Table S1J. * P < 0.05 relative to untreated control