Skip to main content
. 2016 Aug 12;7(36):58181–58192. doi: 10.18632/oncotarget.11276

Figure 2. Caspase-1 and caspase-11 modulate IL-1β release after NLRP-3 activation in lung TAMs.

Figure 2

The inhibition of caspase-1 by means Y-Vad (1 μg/mL) significantly reduced the release of IL-1β after LPS+ATP addition to lung TAMs (A). (B) The genetic absence of both caspase-1 and caspase-11 or of the sole caspase-11 (C) completely abrogated the release of IL-1β from lung TAMs after LPS+ATP stimulation. C3H-derived lung TAMs released reduced levels of IL-1β when LPS+ATP were added (D). Data represent means ± SEM (n = 12). Statistically significant differences are denoted by *, **, ***and **** indicating p < 0.05, p < 0.01, p < 0.005 and p < 0. 001, respectively as determined by Student's t test.