Table 1. Most frequently reported miRNAs in malignant mesothelioma and asbestos exposure evaluated by a traditional vote-counting method.
Comparison status among groups | miRNAs | MM vs. normal tissue / benign proliferations | MM vs. other cancers or different histotypes | MM blood samples vs. normal blood samples | MM cells vs. normal cells | ||||
---|---|---|---|---|---|---|---|---|---|
MiRNAs deregulated in the four comparison categories | miR-17-5p | ↓ | [83] | → | [82], [79] | ↓ | [88] | ↑ | [81], [82] |
miR-20a / miR-20a-5p | ↑ | [80] | → | [79] | ↓ | [88] | ↑ | [81], [82] | |
miR-21 / miR-21-5p | ↑ | [77] | → | [82], [79] | ↓ | [88] | → | [82] | |
miR-29c* / miR-29c-5p | ↓ | [90] | → | [74], [79] | ↑ | [90] | ↓ | [74] | |
miR-30c | ↓ | [85] | → | [82] | ↓ | [88] | ↑ | [82] | |
miR-92 / miR-92a / miR-92a-3p | → | [90] | → | [79] | ↑ | [90] | ↑ | [81] | |
↑ | [80] | ↓ | [88] |
Note: deregulated miRNAs extracted from relevant papers and classified based on four comparison categories: a) MM tissue vs. normal or non-cancer tissue; b) MM tissue vs. other cancer tissues; c) MM blood samples vs. normal blood samples; and d) MM cell lines vs. normal cell lines. MiRNAs are reported as being up-regulated, down-regulated or deregulated based on the relevant studies.
↑: up-regulated, ↓: down-regulated, →: deregulated miRNAs. For the latter clear expression information is not provided in the corresponding article, or they have been found to be deregulated in different MM histotypes. Numbers to the right of each arrow are the references numbered according to the reference list. The new nomenclature is reported where the old miRNA name could be ambiguous. Because of space limitations, the full table and details of miRNA behaviors are reported in Supplementary Table 1.