Table 1. Classification of common cancers based on their molecular profile.

A: Examples of characteristic genetic and cytogenetic events:
Kit Mutations	GIST, Seminoma, Adult mastocytoma, Acute myeloid leukemia, Sinonasal NK cell lymphoma
BRAF mutations	Thyroid cancer, Melanoma, Colorectal carcinoma, Hairy cell leukemia, Brain gliomas
ALK rearrangements	Anaplastic T-cell lymphoma, Diffuse large B-cell lymphoma, Lung adenocarcinoma, Familial neuroblastoma, Inflammatory myofibroblastic tumor, Epithelioid inflammatory myofibroblastic tumor, Spitz tumor, systemic histiocytosis, Renal cell carcinoma
EWS rearrangements	Ewing's sarcoma family, Desmoplastic round cell sarcoma, Extraskeletal myxoid chondrosarcoma, Myoepithelial tumors, Clear cell sarcoma, Angiomatoid fibrous histiocytoma, Myxoid liposarcoma
BAF-deficient or dysregulated tumors	Malignant renal and extrarenal rhabdoid tumors, Atypical rhabdoid teratoid tumor, Epithelioid sarcoma, Epithelioid malignant peripheral sheath tumor, Schwannoma, Renal medullary carcinoma, Sinonasal carcinoma, Vulvar carcinoma, Thoracic carcinoma, Small cell carcinoma of the ovary hypercalcemic type, Synovial carcinoma, Endometrial dedifferentiated carcinoma, Poorly differentiated lung carcinoma
ATRX mutations	Brain gliomas, neuroendocrine tumors, Osteosarcoma, Liver angiosarcoma, Leiomyosarcoma

B: Examples of common signaling transduction pathways over-expressed in various cancers:
EGFR	Lung carcinoma, Breast carcinoma, Head and neck carcinoma, Colon cancer
IGFR	Breast cancer, Ewing's sarcoma, Rhabdomyosarcoma, Fibrosarcoma, GIST
mTOR	Renal cell carcinoma, Breast carcinoma, Sarcomas, Medulloblastoma, Glioblastoma
MAP/PI3k/Akt	Breast carcinoma, Endometrial cancer, Sarcomas
VEGF	Lung carcinoma, Colorectal carcinoma, Gynecologic cervical, Ovarian or fallopian tube carcinomas
Wnt	Colorectal carcinoma, Desmoids, Breast carcinoma, Brain tumors
Sonic Hedgehog	Pancreatic carcinoma, Basal cell carcinoma, Colorectal carcinoma, Metastatic prostate carcinoma, Medulloblastoma
Hippo	Osteosarcoma, Rhabdomyosarcoma, Liver cancer, Medulloblastoma
PDL1	Non-small lung cancer, Breast cancer, Hodgkin's lymphoma, B-cell lymphomas, Renal cell carcinoma, Gastrointestinal malignancies