Table 4. Chlortalidone 25 mg/Amiloride 5 mg (q.d.) or Losartan 50 mg (b.i.d.), Central Systolic Blood Pressure, and AIx 75 of HTN-1 Group.
| Chlortalidone/amiloride |
Losartan |
|||||
|---|---|---|---|---|---|---|
| Mean | SD | 95% CI | Mean | SD | 95% CI | |
| Baseline | ||||||
| CBP, mm Hg | 123.3 | 14.2 | 117.4 - 129.1 | 120.5 | 16.7 | 113.6 - 127.4 |
| AIx 75 | 87.7 | 9.6 | 83.7 - 91.6 | 91.2 | 8.7 | 87.7 - 94.9 |
| 6 months | ||||||
| CBP, mm Hg | 113.4* | 11.4 | 108.9 - 118.2 | 118.4 | 10.6 | 114.1 - 122.8 |
| AIx 75 | 83.8# | 8.9 | 80.1 - 87.4 | 87.6 | 6.8 | 84.8 - 90.4 |
CSBP: central systolic blood pressure; AIx 75: augmentation index corrected for average heart rate of 75 bpm; HTN-1: stage 1 hypertension. Values are expressed as mean ± SD, Standard deviation; 95% CI: 95% confidence interval. *P = 0.0103. #P = 0.0289.