Figure 2.

Predictive functional net clusters yield novel phenotypic enhancing and suppressing human gene pairs. (A) Each horizontal bar represents the set of known genetic interaction partners of a specific human gene; each of these sets is referred to as a “seed set.” High AUC scores indicate that the interaction partners participate together in a cluster in HumanNet, the human functional gene network. Therefore, other members of the cluster are predicted as novel interaction partners. (B) Shown are two examples of well-defined HumanNet clusters that are highly predictive for phenotypic enhancement (left) and suppression (right), with the known interactions from the seed set denoted by the boxed genes and dashed edges.