Table 1. Predictive power of functional networks across different genetic interactions.
| H. sapiens | D. melanogaster | S. cerevisiae | |
|---|---|---|---|
| Dosage growth defect | Not tested | Not tested | 176/488 |
| Dosage lethality | 2/3 | Not tested | 116/201 |
| Dosage rescue | 5/13 | Not tested | 203/638 |
| Phenotypic enhancement | 30/57 | 322/449 | 287/1175 |
| Phenotypic suppression | 36/66 | 398/518 | 223/1088 |
| Synthetic growth defect | 4/37 | Not tested | 576/2436 |
| Synthetic rescue | 2/3 | 5/6 | 218/972 |
| Synthetic lethality | Not tested | Not tested | 221/1469 |
| Negative genetic | Not tested | Not tested | 65/4352 |
| Positive genetic | Not tested | Not tested | 55/2826 |
For each fraction, the numerator indicates the number of seed sets with AUC ≥ 0.9 and the denominator equals the total number of seed sets tested. Definitions of each genetic interaction type are listed in Table S1.