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. 2017 Jan 4;7(2):625–635. doi: 10.1534/g3.116.037788

Figure 2.

Figure 2

Analysis of histone post-translational modifications from bulk histones in upSET mutant cells. (A) Relative quantification (1.0 = 100%) of H4K5K8K12K16 mono-, di-, tri-, and tetra-acetyl patterns in upSET mutant cell lines (G3, B2, and A7), butyrate treated cells (S2but), and the parental S2 line. The patterns of the mutant or butyrate treated cells differ from the parental cell line. Sodium butyrate inhibits deacetylases, resulting in accumulation of acetylation marks. (B) Relative quantification (1.0 = 100%) of H3K9K14 PTM patterns in upSET mutant cell lines (G3, B2, and A7), butyrate treated cells (S2but), and the parental S2 line. The H3K9me2/me3 marks are depleted from upSET mutant S2 cells, suggestive of an effect on heterochromatin.