Table 1. Variants detected by whole genome resequencing of three affected Malinois dogs.
| Filtering Step | Number of Variants |
|---|---|
| Variants in the whole genomea | 938,586 |
| Variants in the critical 1.4 Mb interval on chromosome 38 | 3558 |
| Variants in the critical interval that were absent from 140 other dog genomes | 23 |
| Nonsynonymous variants in the whole genomea | 6007 |
| Nonsynonymous variants in the 1.4 Mb critical interval on chromosome 38 | 48 |
| Nonsynonymous variants in the critical interval, absent from 140 other dog genomes | 2 |
a
The sequences were compared to the reference genome (CanFam 3.1) from a Boxer. Only variants that were homozygous in all three affected Malinois puppies (MA008, MA094, and MA152) are reported. Nonsynonymous variants were classified based on the ENSEMBL annotation (version 72).