Table 3. Significant and suggestive QTL for carotid atherosclerosis identified in combined cross analysis of data from the current cross and the two previously reported crosses.
| Locus | Chr | Trait | LOD | Peak (cM) | 95% C.I. | Peak (Mb) | 95% C.I. (Mb) |
|---|---|---|---|---|---|---|---|
| 2 | Carotid lesion | 2.77 | 80.22 | 44.22–98.22 | 159.59 | 71.96–170.59 | |
| 3 | Carotid lesion | 2.31 | 50.01 | 26.01–64.01 | 114.85 | 56.96–138.77 | |
| Cath7 | 5 | Carotid lesion | 3.84 | 39.05 | 34.19–44.28 | 65.31 | 61.51–69.16 |
| Cath2 | 5 | Carotid lesion | 8.06 | 66.35 | 63.84–70.35 | 127.32 | 124.83–131.29 |
| Cath4 | 6 | Carotid lesion | 2.15 | 66.21 | 1.53–88.79 | 120.60 | 6.44–145.75 |
| Cath8 | 9 | Carotid lesion | 3.92 | 75.33 | 66.37–75.33 | 114.09 | 103.61–114.09 |
| 11 | Carotid lesion | 3.02 | 26.1 | 18.2–32.2 | 45.28 | 30.91–54.19 | |
| 11 | Carotid lesion | 3.32 | 51 | 17.99–69.99 | 83.84 | 30.91–105.15 | |
| Cath1 | 12 | Carotid lesion | 9.95 | 32.59 | 23.47–44.59 | 70.23 | 48.06–88.56 |
| Cath3 | 13 | Carotid lesion | 9.49 | 53.35 | 36.02–56.02 | 100.5 | 68.40–103.48 |
| Cath5 | 15 | Carotid lesion | 2.35 | 11.26 | 3.8–37.8 | 30.76 | 7.87–71.92 |
| 16 | Carotid lesion | 2.94 | 41.66 | 28.95–43.66 | 64.11 | 37.35–72.76 | |
| Cath6 | 18 | Carotid lesion | 3.01 | 39.73 | 31.73–41.73 | 62.50 | 56.27–65.17 |
| 19 | Carotid lesion | 2.74 | 2.43 | 2.43–26.43 | 3.65 | 3.65–36.64 |
LOD score threshold for suggestive QTL was 2.128 and was 3.508 for significant QTL. Significant QTL are highlighted in bold. Chr, chromosome; LOD, logarithm of the odds; QTL, quantitative trait loci.