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The sequential oxidation of l-arginine (L-Arg) into NO and l-citrulline (L-Cit) catalysed by NOS. Initially L-Arg is oxidised to N-hydroxy-l-arginine (NHA) which is further oxidised to L-Cit and NO. Electrons transfer from the NOS FMN hydroquinone to the NOS oxygenase domain is thought to be cross dimer and only occurs when CaM is bound.
