Table 5. Overview of selected benefits and harms (per 100,000 individuals alive at the start of 2015) of the screening scenarios on the efficient frontier (effect estimates are not discounted).

Scenario #*	Percentage of the total population ever screened	CT screens and follow-up examinations (per 100,000)	Lung cancer mortality reduction in the total population (%)	Lung cancer deaths prevented† (per 100,000)	Life-years gained (per 100,000)	Average number of life-years gained per lung cancer death averted	Percentage of screen-detected cancers that are overdiagnosed	Number of overdiagnosed lung cancers (per 100,000)‡	False-positive screens (per 100,000)	Number of non-lung cancer surgeries due to screening§ (per 100,000)	Biopsies due to screening§ (per 100,000)
#1	8.74%	73,248	8.24%	229	2,170	9.48	13.06%	80	11,937	132	283
#2	9.56%	91,692	9.05%	251	2,531	10.08	12.53%	82	14,729	163	350
#3	13.03%	125,320	10.50%	292	2,993	10.25	12.31%	93	20,145	223	479
#4	13.04%	135,410	11.71%	325	3,159	9.72	14.43%	127	21,575	239	514
#5	15.41%	161,159	11.93%	331	3,388	10.24	12.34%	106	25,698	285	612
#6	15.42%	177,014	13.58%	377	3,624	9.61	14.68%	150	27,947	311	667
#7	16.06%	225,062	15.71%	436	4,129	9.47	14.89%	176	34,933	390	838
#8	16.06%	255,207	17.32%	481	4,422	9.19	15.48%	203	39,228	438	943
#9	16.19%	270,354	17.59%	489	4,577	9.36	15.36%	204	41,414	463	997
#10	19.99%	355,448	19.51%	542	5,142	9.49	15.15%	221	54,259	607	1,308
#11	26.13%	473,383	21.92%	609	5,774	9.48	15.14%	248	72,221	809	1,742

* Scenario details are provided in Table 4.

† Number of lung cancer deaths per 100,000 without screening: 2,777.

‡ Number of lung cancer cases per 100,000 without screening: 3,522.

§ For persons in whom lung cancer was not detected by screening.